What is 4,5,6-Trifluoropyrimidine?
4,5,6 trifluoropyrimidine is a Halogenated Heterocyclesan. It is a building block and intermediate that is very valuable in the synthesis of new fungicide. The study of its preparation and feasible development process for industrial manufacturing is very meaningful for practice.
Preparation of 4,5,6-trifluoro-pyrimidine
Use 4,6-dichloro-5-fluorine pyrimidine as a raw material and reacting under ordinary pressure with a fluorinated reagent, a phase-transfer catalyst and a high-polarity aprotic solvent. The advantages of the preparation method are that the reaction process conditions are simple, the reaction temperature is low, the reaction time is short, and the production cost is low because that reaction under ordinary pressure exempts the reaction from high-pressure equipment. More importantly, the yield of the obtained product is as high as more than 80% and the purity can be higher than 97%.
By contrast, in the method reported by German Price Cech, Macho Stewart, only raw materials are used and 4,5,6-trifluoropyrimidine is prepared directly by a one-step reaction. However, the process conditions are harsh. The reaction requires high pressure, high reaction temperature, and special catalyst. The catalyst is very unstable in air and an inert gas needs to be used.
4,5,6-trifluoro-pyrimidine can be prepared from diethyl fluoromalonate or dimethyl fluoromalonate.
Banff Green Technologies, Inc. is a technologically innovative company that focuses on chemicals, materials, pharmaceuticals, crop science and environmental technology. The company headquarter is based in Shanghai, China. Our research and development team is comprised of a talented and experienced team of PhD’s with strong scientific backgrounds dedicated to our mission. We are also supported by strong infrastructure, which include state of the art lab facilities, two pilot facilities and seven manufacturing sites located in five provinces in China.
Our core businesses span over the following areas: R & D, production and sales of fine and specialty chemicals, contract manufacturing services and custom synthesis.
Our main products are: fluorinated fine chemicals (mainly Diethyl fluoromalonate and 5- fluorine pyrimidine derivatives), chiral compounds (amino acids and their derivatives, in particular D-Valine, L-Valine, L-2-Aminobutyric acid, L-2-Aminobutanamide hydrochloride, chloramphenicol and Valnemulin hydrochloride).
Our corporate mission is to achieve environmental protection and sustainability while being socially responsible through our research and innovation. We sincerely hope to better serve our customers through every facets of their needs and together we can achieve a more sustainable future.