Diethyl fluoromalonate,CAS 685-88-1

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Product Description
What is diethyl fluoromalonate?

Diethyl fluoromalonate, CAS number 685-88-1, is an organic intermediate widely used in the fields of pharmaceuticals, agricultural chemicals, materials, dyestuff, industrial additives, etc. It is also known as diethyl 2-fluoromalonate, 1,3-diethyl 2-fluoropropanedioate, 2-fluoro-malonic acid diethyl ester, fluoromalonic acid diethyl ester, Ethyl fluoromalonate, etc.
Product Feature
Our advantages:

Environmental friendly and risk free

Our novel manufacturing process is much more environmental friendly than the traditional process. The traditional process emits HF which is extremely toxic and corrosive and a mixture of methylbenzene and triethylamine which are also toxic and difficult to contain. In contrast, our process does not involve any of these materials. Thus, our wastes can be easily treated and reach the emission standard.

Higher purity

Our diethyl fluoromalonate can reach as high as 99% purity (by GC), and is the highest assay that is commercially available. The common purity of diethyl fluoromalonate on the market is about 90% and it is difficult to further purify.

Bulk stock

As diethyl fluoromalonate is one of Banff's most important products, a large stock is available all year round.
Application / Models
The already known key applications of Diethyl fluoromalonate include: used as pharmaceutical intermediate, in synthesizing fungicides, special materials, dyestuff, enzymeu00a0inhibitors, fluoride-containing amino acids, fluoride-containing Chalcone, sedative, etc. The research and industrialization of diethyl fluoromalonate is stillu00a0atu00a0theu00a0beginningu00a0stage, and more applications will be explored in the future.

Diethyl fluoromalonate as pharmaceutical intermediate

Diethyl fluoromalonate has been shown to be a valuable intermediate in the synthesis of alpha-fluoroalkanoic acids, including y-fluoroglutamic acid. It is also an intermediate for 5-Fluoropyrimidine (CAS 675-21-8) compounds, which shows good bioactivities for anti-cancer, antibacterial effects.

Diethyl fluoromalonate used in agricultural chemical industry

Diethyl fluoromalonate is an important intermediate for the synthesis of environment-friendly fungicide Fluoxastrobin developed by Bayer CropScience in 2005. Fluoxastrobin, commonly used in Fandango, Fortix, Scenic, DISARM, EVITO, and HEC 480 SC (trade names), is a new strobilurin fungicide active ingredient for the control of fungal diseases such as early blight, late blight, leaf spots, leaf rust, and Rhizoctonia solani.

Diethyl fluoromalonate for special materials

New functional fluorinated materials are rapidly emerging to meet the demanding requirements of advanced applications in fields as diverse as sensing, catalysis and environmental protection due to its excellent prosperities such as chemical resistance, heat endurance, dielectricity, noninflammability, non-sticku00a0performanceu00a0andu00a0wear-resistance. AS per Journal of Materials Chemistry, fluororesin,u00a0fluoroelastomers, and fluorosilicone (FRS) are very popular fluoride-containing materials widely used in the fields of photoelectrons, fiberu00a0optic, etc. Diethyl fluoromalonate can be used as the starting material for many of these specialty materials.

Diethyl fluoromalonate in synthesizing 4,5,6-Trifluoropyrimidine and dyestuff

More information is to be updated for the mechanism of action of diethyl fluoromalonate for the preparation of 4,5,6-Trifluoropyrimidine (CAS 17573-78-3). 4,5,6-Trifluoropyrimidine is an important pesticide intermediate and it is also applied as an intermediate dye industry.

Diethyl fluoromalonate in preparing enzymeu00a0inhibitors

According to Wikipedia, fluoride salts are commonly used in biological assay processing tou00a0inhibitu00a0the activity ofu00a0phosphatases, such asu00a0serine/threoninephosphatases. Fluoride mimics theu00a0nucleophilicu00a0hydroxideu00a0ion in these enzymes' active sites.Beryllium fluorideu00a0andu00a0aluminium fluorideu00a0are also used as phosphatase inhibitors, since these compounds are structural mimics of theu00a0phosphateu00a0group and can act as analogues of theu00a0transition stateu00a0of the reaction. Diethyl fluoromalonate can be used to various synthesize enzyme inhibitors.

Diethyl fluoromalonate can also be used to prepare fluoride-containing amino acids, fluoride-containing Chalcone, fluorotetrahydroquinolines, and sedative areas.
Banff Green Technologies, Inc. is a technologically innovative company that focuses on chemicals, materials, pharmaceuticals, crop science and environmental technology. The company headquarter is based in Shanghai, China. Our research and development team is comprised of a talented and experienced team of PhD’s with strong scientific backgrounds dedicated to our mission. We are also supported by strong infrastructure, which include state of the art lab facilities, two pilot facilities and seven manufacturing sites located in five provinces in China.

Our core businesses span over the following areas: R & D, production and sales of fine and specialty chemicals, contract manufacturing services and custom synthesis.

Our main products are: fluorinated fine chemicals (mainly Diethyl fluoromalonate and 5- fluorine pyrimidine derivatives), chiral compounds (amino acids and their derivatives, in particular D-Valine, L-Valine, L-2-Aminobutyric acid, L-2-Aminobutanamide hydrochloride, chloramphenicol and Valnemulin hydrochloride).

Our corporate mission is to achieve environmental protection and sustainability while being socially responsible through our research and innovation. We sincerely hope to better serve our customers through every facets of their needs and together we can achieve a more sustainable future.

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Banff Green Technologies, Inc.

China China
Contact Person: Xue Yang
Telephone: 86-21-54795870
Location: Shanghai, China
Business Type:Manufacturer, Importer, Service
Main Target Region:World Wide
Floor 29, CapitaMalls Plaza, No. 6088 Humin Rd., Minhang Dist.
Main Product:
dimethyl fluoromalonate, diethyl fluoromalonate, d-p-methyl sulfone phenyl ethyl serinate, florfenicol, d-(-)-threo-2-amino-1-(4-nitrophenyl)-1,3-propanediol, chloramphenicol
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