What is amentoflavone?
Amentoflavone is the active ingredient extracted from Chinese plant Selaginella tamariscina, belonging to the family of Selaginellaceae. Both selaginella tamariscina and its compound amentoflavone may be new to most bodybuilders and athletes who want to build muscles and enhance performance. However, amentoflavone has been registered in Chinese Pharmacopeia (CP2005 Edition) and used in China for decades for anti-cancer, anti-inflammatory, anti-virus, analgesia, lowering blood pressure, lowering blood glucose and strengthening the role of immune functions.
Nowadays amentoflavone has been used in sports nutrition formulas by supplements manufacturers, like AmentoMax from Analyzed Supplements, CONQU3R "Demigod Edition" (Stim-Free) from Olympus Labs, F5 from NutraClipse Inc, High Volume from PES Science(Physique Enhancing Science), Uncut from Applied Nutriceuticals and many other sports brands.
As a biflavanoid, amentoflavone is famous for its ability to directly enhance strength. Moreover, amentoflavone is proved to help fat loss and improve insulin sensitivity, making it a versatile compound in any pre workouts and fat burners. We will illustrate its benefits and applications in details below. There are plenty of studies and scientific researches on amentoflavone, you may find more information on pubmed.
Natural sources of amentoflavone
There are many plant sources for amentoflavone, according to Wikipedia, the most popular ones include ginkgo biloba, St John's Wort (Hypericum perforatum), Chamaecyparis obtuse(hinoki), Xerophyta plicata, etc. All these plants are native to China, and may not be able to find somewhere else in other countries. However, amentoflavone has the highest content and most easily available in Selaginella Tamariscina extract, and the specification amentoflavone 20% is the most popular spec, and every company use 20% amentoflavone in their supplement. Of course, amentoflavone 30%, 50% are also available, but the price is relatively high accordingly.
Chemical constituents of Selaginella Tamariscina
Selaginellaceae has only a genus of Selaginella Tamariscina, distributed extensively in China. The chemical components in it are complicated, and biflavones are the most researched ingredients by chemists, amentoflavone as its typical representative. The bioflavones are composed by apigenin or apigenin derivatives(like 6-(5-carboxyl-2-methoxyphenyl)-apigenin or 6-(2-Hydroxy-5-acetylphenyl)-apigenin) combined by C-C or C-O-C link. The popular bioflavones include Hinokiflavone, Robustaflavone, Delicaflavone, and amentoflavone.
Phenylpropanoids is another important chemical items in selaginella tamariscina plant. As early as 1994, Lin-RC had initially isolated five ligans lactones, (-)-lirioresinol A, B, Wikstromol, nortrachel0side, matairesinol, Selaginellin A, globularin B, globularin C, etc. Many more components are yet to be discovered.
Mechanism of action of amentoflavone
How does amentoflavone work? Let's start with strength. We have to know the relation between strength and calcium. The final trigger in muscle contraction is an increase in calcium in the muscle cell. The calcium binds to key muscle proteins that result in contraction, and it has been shown that the more calcium released into the muscle cell, the stronger the contraction. Amentoflavone possesses the highly unique ability to increase calcium release in vitro. In fact, only one other common compound shares this mechanism: caffeine. Unlike caffeine though, Amentoflavone is 20 times stronger at increasing muscle calcium than caffeine in vitro.
In addition, Amentoflavone is a PDE inhibitor, which is a well-known mechanism of vasodilatation.
Amentoflavone's ability to inhibit PDE comes in handy not just for those looking for the performance and pump benefits of PDE inhibition, but this mechanism is also associated with improved lipolysis.
Amentoflavone also inhibits Fatty Acid Synthase in vitro therefore acting on the opposite side of the coin by preventing the body from forming new fa
Selaginella Tamariscina extract Amentoflavone 20%
Botanical source:Selaginella tamariscina (Beauv.) Spring
Brown to light yellow powder
Enhance muscular strength, lose weight
Product Specification / Models
20% Amentoflavone, 30%, 50%,98%
Application / Models
Fat burner, sports nutrition, cosmetics
Herb Nutritionals Co., ltd, located in Shanghai, China, is an innovative natural products manufacturer, supplier and marketer that manufactures, supplies, develops and commercializes raw ingredients and science-based solutions to the dietary supplements, food and beverage, sports nutrition, nootropics, specialty fine chemicals, cosmetic and pharmaceutical industries. Herb Nutritionals Co., Ltd possesses approximately 100 employees and occupied plant area of 40000 m2 while half is under construction, and it operates large scale of extraction and spray drying equipment allowing for mass production in a short time.
In dietary supplements, herbal extracts, botanicals, phytochemicals are the main products we focus. As our company name “Herbal nutritionals” indicates, any nutritional ingredients derived from Traditional Chinese herbs（TCM）, botanicals are our key emphasis. The ingredient portfolio includes Alpha GPC,polydatin 98%,Neohesperidin dihydrochalcone(NHDC), nicotinamide riboside (NR), Nicotinamide Adenine Dinucleotide(NAD,NADH), Black rice extract(cyanidin-3-glucoside/C3G), astaxanthin, resveratrol (Polygonum cuspidatum), glutathione reduced,Gotu Kola extract,apigenin, Pterostilbene 99%, Epimedium extract Icariin, Green Coffee Bean extract, Mucuna pruriens L-dopa, Vinpocetine,PQQ disodium salt,etc.
Nootropics are a brand-new product line of herb Nutritionals Co., Ltd according to the market demand. Nootropics are also referred to as smart drugs, memory enhancers, neuro enhancers, cognitive enhancers, brain pills, intelligence enhancers that improve one or more aspects of mental function, such as working memory, motivation, mood, and attention. Nootropics are a relatively new class of supplements and pharmaceuticals with top five benefits include: increased memory, Enhanced Mental Clarity and Focus, Improved Mood and Stress Reduction, Enhanced Neuroplasticity and Better Overall Brain Health.